Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols

Yuchao Zhu, Kaimeng Huang, Jun Pan, Xu Qiu, Xiao Luo, Qixue Qin, Jialiang Wei, Xiaojin Wen, Lizhi Zhang and Ning Jiao ()
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Yuchao Zhu: Peking University
Kaimeng Huang: Peking University
Jun Pan: Peking University
Xu Qiu: Peking University
Xiao Luo: Peking University
Qixue Qin: Peking University
Jialiang Wei: Peking University
Xiaojin Wen: Peking University
Lizhi Zhang: Peking University
Ning Jiao: Peking University

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp3-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C–C bond formation of simple alkanols.

Date: 2018
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DOI: 10.1038/s41467-018-05014-w

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