Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

Daniel Torralba, Francesc Baixauli, Carolina Villarroya-Beltri, Irene Fernández-Delgado, Ana Latorre-Pellicer, Rebeca Acín-Pérez, Noa B Martín-Cófreces, Ángel Luis Jaso-Tamame, Salvador Iborra, Inmaculada Jorge, Gloria González-Aseguinolaza, Johan Garaude, Miguel Vicente-Manzanares, José Antonio Enríquez, María Mittelbrunn and Francisco Sánchez-Madrid ()
Additional contact information
Daniel Torralba: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Francesc Baixauli: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Carolina Villarroya-Beltri: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Irene Fernández-Delgado: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Ana Latorre-Pellicer: Universidad de Santiago de Compostela
Rebeca Acín-Pérez: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Noa B Martín-Cófreces: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Ángel Luis Jaso-Tamame: Imperial College Faculty of Medicine
Salvador Iborra: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Inmaculada Jorge: Melchor Fernández Almagro 3
Gloria González-Aseguinolaza: Universidad de Navarra
Johan Garaude: Centro Nacional Investigaciones Cardiovasculares (CNIC)
Miguel Vicente-Manzanares: Instituto de Biología Molecular y Celular del Cáncer USAL-CSIC
José Antonio Enríquez: Centro Nacional Investigaciones Cardiovasculares (CNIC)
María Mittelbrunn: Hospital 12 de Octubre (i+12)
Francisco Sánchez-Madrid: Centro Nacional Investigaciones Cardiovasculares (CNIC)

Nature Communications, 2018, vol. 9, issue 1, 1-17

Abstract: Abstract Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05077-9

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DOI: 10.1038/s41467-018-05077-9

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