A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems

Yue Sun, Fan Zhang, Jiaxin Quan, Fei Zhu, Wei Hong, Junkai Ma, Huan Pang, Yao Sun, Demei Tian and Haibing Li ()
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Yue Sun: Central China Normal University
Fan Zhang: Central China Normal University
Jiaxin Quan: Central China Normal University
Fei Zhu: Central China Normal University
Wei Hong: Central China Normal University
Junkai Ma: Central China Normal University
Huan Pang: Central China Normal University
Yao Sun: Central China Normal University
Demei Tian: Central China Normal University
Haibing Li: Central China Normal University

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Inspired by glucose-sensitive ion channels, herein we describe a biomimetic glucose-enantiomer-driven ion gate via the introduction of the chiral pillar[6]arene-based host–guest systems into the artificial nanochannels. The chiral nanochannels show a high chiral-driven ionic gate for glucose enantiomers and can be switched “off” by d-glucose and be switched “on” by l-glucose. Remarkably, the chiral nanochannel also exhibited a good reversibility toward glucose enantiomers. Further research indicates that the switching behaviors differed due to the differences in binding strength between chiral pillar[6]arene and glucose enantiomers, which can lead to the different surface charge within nanochannel. Given these promising results, the studies of chiral-driven ion gates may not only give interesting insight for the research of biological and pathological processes caused by glucose-sensitive ion channels, but also help to understand the origin of the high stereoselectivity in life systems.

Date: 2018
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DOI: 10.1038/s41467-018-05103-w

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