NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer

Peiyuan Wang, Yong Fan, Lingfei Lu, Lu Liu, Lingling Fan (), Mengyao Zhao, Yang Xie, Congjian Xu and Fan Zhang ()
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Peiyuan Wang: Fudan University
Yong Fan: Fudan University
Lingfei Lu: Fudan University
Lu Liu: Fudan University
Lingling Fan: Fudan University
Mengyao Zhao: Fudan University
Yang Xie: Second Military Medical University
Congjian Xu: Fudan University
Fan Zhang: Fudan University

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract Local recurrence is a common cause of treatment failure for patients with solid tumors. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and, thereby improve prognosis. Here, we report in vivo assembly of the second near-infrared window (NIR-II) emitting downconversion nanoparticles (DCNPs) modified with DNA and targeting peptides to improve the image-guided surgery for metastatic ovarian cancer. The NIR-II imaging quality with DCNPs is superior to that of clinically approved ICG with good photostability and deep tissue penetration (8 mm). Stable tumor retention period experienced 6 h by in vivo assembly of nanoprobes can be used for precise tumor resection. Superior tumor-to-normal tissue ratio is successfully achieved to facilitate the abdominal ovarian metastases surgical delineation. Metastases with ≤1 mm can be completely excised under NIR-II bioimaging guidance. This novel technology provides a general new basis for the future design of nanomaterials for medical applications.

Date: 2018
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DOI: 10.1038/s41467-018-05113-8

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