APC2 controls dendrite development by promoting microtubule dynamics

Olga I. Kahn, Philipp Schätzle, Dieudonnée van de Willige, Roderick P. Tas, Feline W. Lindhout, Sybren Portegies, Lukas C. Kapitein and Casper C. Hoogenraad ()
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Olga I. Kahn: Utrecht University
Philipp Schätzle: Utrecht University
Dieudonnée van de Willige: Utrecht University
Roderick P. Tas: Utrecht University
Feline W. Lindhout: Utrecht University
Sybren Portegies: Utrecht University
Lukas C. Kapitein: Utrecht University
Casper C. Hoogenraad: Utrecht University

Nature Communications, 2018, vol. 9, issue 1, 1-17

Abstract: Abstract Mixed polarity microtubule organization is the signature characteristic of vertebrate dendrites. Oppositely oriented microtubules form the basis for selective cargo trafficking in neurons, however the mechanisms that establish and maintain this organization are unclear. Here, we show that APC2, the brain-specific homolog of tumor-suppressor protein adenomatous polyposis coli (APC), promotes dynamics of minus-end-out microtubules in dendrites. We found that APC2 localizes as distinct clusters along microtubule bundles in dendrites and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. Depletion of APC2 reduces the plus end dynamics of minus-end-out oriented microtubules, increases microtubule sliding, and causes defects in dendritic morphology. We propose a model in which APC2 regulates dendrite development by promoting dynamics of minus-end-out microtubules.

Date: 2018
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DOI: 10.1038/s41467-018-05124-5

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