Ratiometric nanothermometer in vivo based on triplet sensitized upconversion

Ming Xu, Xianmei Zou, Qianqian Su, Wei Yuan, Cong Cao, Qiuhong Wang, Xingjun Zhu, Wei Feng () and Fuyou Li ()
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Ming Xu: Fudan University
Xianmei Zou: Fudan University
Qianqian Su: Fudan University
Wei Yuan: Fudan University
Cong Cao: Fudan University
Qiuhong Wang: Fudan University
Xingjun Zhu: Fudan University
Wei Feng: Fudan University
Fuyou Li: Fudan University

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Temperature is an essential factor that counts for living systems where complicated vital activities are usually temperature dependent. In vivo temperature mapping based on non-contact optical approach will be beneficial for revealing the physiological phenomena behind with minimized influence to the organism. Herein, a highly thermal-sensitive upconversion system based on triplet–triplet annihilation (TTA) mechanism is pioneered to indicate body temperature variation sensitively over the physiological temperature range. The temperature-insensitive NaYF4: Nd nanophosphors with NIR emission was incorporated into the temperature-responsive TTA-upconversion system to serve as an internal calibration unit. Consequently, a ratiometric thermometer capable of accurately monitoring the temperature changes in vivo was developed with high thermal sensitivity (~7.1% K−1) and resolution (~0.1 K).

Date: 2018
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DOI: 10.1038/s41467-018-05160-1

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