Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly

Yumin Chen, Ke Deng (), Shengbin Lei, Rong Yang, Tong Li, Yuantong Gu, Yanlian Yang (), Xiaohui Qiu () and Chen Wang ()
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Yumin Chen: National Center for Nanoscience and Technology, China
Ke Deng: National Center for Nanoscience and Technology, China
Shengbin Lei: Tianjin University
Rong Yang: National Center for Nanoscience and Technology, China
Tong Li: Queensland University of Technology
Yuantong Gu: Queensland University of Technology
Yanlian Yang: National Center for Nanoscience and Technology, China
Xiaohui Qiu: National Center for Nanoscience and Technology, China
Chen Wang: National Center for Nanoscience and Technology, China

Nature Communications, 2018, vol. 9, issue 1, 1-8

Abstract: Abstract Homochirality is very important in the formation of advanced biological structures, but the origin and evolution mechanisms of homochiral biological structures in complex hierarchical process is not clear at the single-molecule level. Here we demonstrate the single-molecule investigation of biological homochirality in the hierarchical peptide assembly, regarding symmetry break, chirality amplification, and chirality transmission. We find that homochirality can be triggered by the chirality unbalance of two adsorption configuration monomers. Co-assembly between these two adsorption configuration monomers is very critical for the formation of homochiral assemblies. The site-specific recognition is responsible for the subsequent homochirality amplification and transmission in their hierarchical assembly. These single-molecule insights open up inspired thoughts for understanding biological homochirality and have general implications for designing and fabricating artificial biomimetic hierarchical chiral materials.

Date: 2018
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DOI: 10.1038/s41467-018-05218-0

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