The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

Jennifer Ma, Jeremy Setton, Nancy Y. Lee, Nadeem Riaz and Simon N. Powell ()
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Jennifer Ma: Memorial Sloan Kettering Cancer Center
Jeremy Setton: Memorial Sloan Kettering Cancer Center
Nancy Y. Lee: Memorial Sloan Kettering Cancer Center
Nadeem Riaz: Memorial Sloan Kettering Cancer Center
Simon N. Powell: Memorial Sloan Kettering Cancer Center

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Cancer is fundamentally a disease of the genome and inherited deficiencies in DNA repair pathways are well established to increase lifetime cancer risk. Computational analysis of pan-cancer data has identified signatures of mutational processes thought to be responsible for the pattern of mutations in any given cancer. These analyses identified altered DNA repair pathways in a much broader spectrum of cancers than previously appreciated with significant therapeutic implications. The development of DNA repair deficiency biomarkers is critical to the implementation of therapeutic targeting of repair-deficient tumors, using either DNA damaging agents or immunotherapy for the personalization of cancer therapy.

Date: 2018
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DOI: 10.1038/s41467-018-05228-y

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