Drug capture materials based on genomic DNA-functionalized magnetic nanoparticles

Carl M. Blumenfeld, Michael D. Schulz, Mariam S. Aboian, Mark W. Wilson, Terilynn Moore, Steven W. Hetts and Robert H. Grubbs ()
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Carl M. Blumenfeld: California Institute of Technology
Michael D. Schulz: California Institute of Technology
Mariam S. Aboian: University of California-San Francisco
Mark W. Wilson: University of California-San Francisco
Terilynn Moore: University of California-San Francisco
Steven W. Hetts: University of California-San Francisco
Robert H. Grubbs: California Institute of Technology

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Chemotherapy agents are notorious for producing severe side-effects. One approach to mitigating this off-target damage is to deliver the chemotherapy directly to a tumor via transarterial infusion, or similar procedures, and then sequestering any chemotherapeutic in the veins draining the target organ before it enters the systemic circulation. Materials capable of such drug capture are yet to be fully realized. Here, we report the covalent attachment of genomic DNA to iron-oxide nanoparticles. With these magnetic materials, we captured three common chemotherapy agents—doxorubicin, cisplatin, and epirubicin—from biological solutions. We achieved 98% capture of doxorubicin from human serum in 10 min. We further demonstrate that DNA-coated particles can rescue cultured cardiac myoblasts from lethal levels of doxorubicin. Finally, the in vivo efficacy of these materials was demonstrated in a porcine model. The efficacy of these materials demonstrates the viability of genomic DNA-coated materials as substrates for drug capture applications.

Date: 2018
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DOI: 10.1038/s41467-018-05305-2

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