Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

Axel Weber (), Sigrid C. Schwarz, Jörg Tost, Dietrich Trümbach, Pia Winter, Florence Busato, Pawel Tacik, Anita C. Windhorst, Maud Fagny, Thomas Arzberger, Catriona McLean, John C. Swieten, Johannes Schwarz, Daniela Vogt Weisenhorn, Wolfgang Wurst, Till Adhikary, Dennis W. Dickson, Günter U. Höglinger () and Ulrich Müller ()
Additional contact information
Axel Weber: Justus-Liebig-Universität
Sigrid C. Schwarz: Technische Universität München
Jörg Tost: CEA—Institut de Biologie Francois Jacob
Dietrich Trümbach: Helmholtz Center München
Pia Winter: Justus-Liebig-Universität
Florence Busato: CEA—Institut de Biologie Francois Jacob
Pawel Tacik: Mayo Clinic
Anita C. Windhorst: Justus-Liebig-Universität
Maud Fagny: CEA—Institut de Biologie Francois Jacob
Thomas Arzberger: German Center for Neurodegenerative Diseases (DZNE)
Catriona McLean: Victorian Brain Bank
John C. Swieten: Erasmus Medical Centre
Johannes Schwarz: Technische Universität München
Daniela Vogt Weisenhorn: German Center for Neurodegenerative Diseases (DZNE)
Wolfgang Wurst: German Center for Neurodegenerative Diseases (DZNE)
Till Adhikary: Philipps University
Dennis W. Dickson: Mayo Clinic
Günter U. Höglinger: Technische Universität München
Ulrich Müller: Justus-Liebig-Universität

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Genetic, epigenetic, and environmental factors contribute to the multifactorial disorder progressive supranuclear palsy (PSP). Here, we study epigenetic changes by genome-wide analysis of DNA from postmortem tissue of forebrains of patients and controls and detect significant (P

Date: 2018
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DOI: 10.1038/s41467-018-05325-y

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