A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

Tyler R. Schleicher, Jing Yang, Marianna Freudzon, Alison Rembisz, Samuel Craft, Madeleine Hamilton, Morven Graham, Godfree Mlambo, Abhai K. Tripathi, Yue Li, Peter Cresswell, Photini Sinnis, George Dimopoulos and Erol Fikrig ()
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Tyler R. Schleicher: Yale University School of Medicine
Jing Yang: Yale University School of Medicine
Marianna Freudzon: Yale University School of Medicine
Alison Rembisz: Yale University School of Medicine
Samuel Craft: Yale University School of Medicine
Madeleine Hamilton: Yale University School of Medicine
Morven Graham: Yale University School of Medicine
Godfree Mlambo: Johns Hopkins University
Abhai K. Tripathi: Johns Hopkins University
Yue Li: Yale University School of Medicine
Peter Cresswell: Yale University School of Medicine
Photini Sinnis: Johns Hopkins University
George Dimopoulos: Johns Hopkins University
Erol Fikrig: Yale University School of Medicine

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract The key step during the initiation of malaria is for motile Plasmodium parasites to exit the host dermis and infect the liver. During transmission, the parasites in the form of sporozoites, are injected together with mosquito saliva into the skin. However, the contribution of vector saliva to sporozoite activity during the establishment of the initial infection of the liver is poorly understood. Here we identify a vector protein by mass spectrometry, with similarity to the human gamma interferon inducible thiol reductase (GILT), that is associated with saliva sporozoites of infected Anopheles mosquitoes and has a negative impact on the speed and cell traversal activity of Plasmodium. This protein, referred to as mosquito GILT (mosGILT) represents an example of a protein found in mosquito saliva that may negatively influence sporozoite movement in the host and could lead to new approaches to prevent malaria.

Date: 2018
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DOI: 10.1038/s41467-018-05374-3

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