Regulation of striatal cells and goal-directed behavior by cerebellar outputs

Le Xiao, Caroline Bornmann, Laetitia Hatstatt-Burklé and Peter Scheiffele ()
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Le Xiao: Biozentrum, University of Basel
Caroline Bornmann: Biozentrum, University of Basel
Laetitia Hatstatt-Burklé: Biozentrum, University of Basel
Peter Scheiffele: Biozentrum, University of Basel

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract The cerebellum integrates descending motor commands and sensory information to generate predictions and detect errors during ongoing behaviors. Cerebellar computation has been proposed to control motor but also non-motor behaviors, including reward expectation and cognitive flexibility. However, the organization and functional contribution of cerebellar output channels are incompletely understood. Here, we elaborate the cell-type specificity of a broad connectivity matrix from the deep cerebellar nuclei (DCN) to the dorsal striatum in mice. Cerebello-striatal connections arise from all deep cerebellar subnuclei and are relayed through intralaminar thalamic nuclei (ILN). In the dorsal striatum, these connections target medium spiny neurons, but also ChAT-positive interneurons, a class of tonically active interneurons implicated in shifting and updating behavioral strategies. Chemogenetic silencing of cerebello-striatal connectivity modifies function of striatal ChAT-positive interneurons. We propose that cerebello-striatal connections relay cerebellar computation to striatal circuits for goal-directed behaviors.

Date: 2018
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DOI: 10.1038/s41467-018-05565-y

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