A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy

Letao Yang, Sy-Tsong Dean Chueng, Ying Li, Misaal Patel, Christopher Rathnam, Gangotri Dey, Lu Wang, Li Cai and Ki-Bum Lee ()
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Letao Yang: The State University of New Jersey
Sy-Tsong Dean Chueng: The State University of New Jersey
Ying Li: The State University of New Jersey
Misaal Patel: The State University of New Jersey
Christopher Rathnam: The State University of New Jersey
Gangotri Dey: The State University of New Jersey
Lu Wang: The State University of New Jersey
Li Cai: The State University of New Jersey
Ki-Bum Lee: The State University of New Jersey

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neurite outgrowth in vivo. Addressing these hurdles, scientists have designed bioscaffolds that mimic the natural tissue microenvironment to deliver physical and soluble cues. However, several significant obstacles including burst release of drugs, insufficient cellular adhesion support, and slow scaffold degradation rate remain to be overcome before the full potential of bioscaffold–based stem-cell therapies can be realized. To this end, we developed a biodegradable nanoscaffold-based method for enhanced stem cell transplantation, differentiation, and drug delivery. These findings collectively support the therapeutic potential of our biodegradable hybrid inorganic (BHI) nanoscaffolds for advanced stem cell transplantation and neural tissue engineering.

Date: 2018
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DOI: 10.1038/s41467-018-05599-2

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