JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin

Karmveer Singh, Emanuela Camera, Linda Krug, Abhijit Basu, Rajeev Kumar Pandey, Saira Munir, Meinhard Wlaschek, Stefan Kochanek, Marina Schorpp-Kistner, Mauro Picardo, Peter Angel, Catherin Niemann, Pallab Maity () and Karin Scharffetter-Kochanek ()
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Karmveer Singh: Ulm University
Emanuela Camera: San Gallicano Dermatologic Institute (IRCCS)
Linda Krug: Ulm University
Abhijit Basu: Ulm University
Rajeev Kumar Pandey: Ulm University
Saira Munir: Ulm University
Meinhard Wlaschek: Ulm University
Stefan Kochanek: Ulm University
Marina Schorpp-Kistner: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
Mauro Picardo: San Gallicano Dermatologic Institute (IRCCS)
Peter Angel: German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
Catherin Niemann: University of Cologne
Pallab Maity: Ulm University
Karin Scharffetter-Kochanek: Ulm University

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract Transcription factors ensure skin homeostasis via tight regulation of distinct resident stem cells. Here we report that JunB, a member of the AP-1 transcription factor family, regulates epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors and by suppressing lineage infidelity. JunB deficiency in basal progenitors results in a dermatitis-like syndrome resembling seborrheic dermatitis harboring structurally and functionally impaired sebaceous glands with a globally altered lipid profile. A fate switch occurs in a subset of JunB deficient epidermal progenitors during wound healing resulting in de novo formation of sebaceous glands. Dysregulated Notch signaling is identified to be causal for this phenotype. In fact, pharmacological inhibition of Notch signaling can efficiently restore the lineage drift, impaired epidermal differentiation and disrupted barrier function in JunB conditional knockout mice. These findings define an unprecedented role for JunB in epidermal-pilosebaceous stem cell homeostasis and its pathology.

Date: 2018
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DOI: 10.1038/s41467-018-05726-z

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