Visual and modular detection of pathogen nucleic acids with enzyme–DNA molecular complexes

Nicholas R. Y. Ho, Geok Soon Lim, Noah R. Sundah, Diana Lim, Tze Ping Loh and Huilin Shao ()
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Nicholas R. Y. Ho: National University of Singapore
Geok Soon Lim: National University of Singapore
Noah R. Sundah: National University of Singapore
Diana Lim: National University Hospital
Tze Ping Loh: National University of Singapore
Huilin Shao: National University of Singapore

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Rapid, visual detection of pathogen nucleic acids has broad applications in infection management. Here we present a modular detection platform, termed enzyme-assisted nanocomplexes for visual identification of nucleic acids (enVision). The system consists of an integrated circuit of enzyme–DNA nanostructures, which function as independent recognition and signaling elements, for direct and versatile detection of pathogen nucleic acids from infected cells. The built-in enzymatic cascades produce a rapid color readout for the naked eye; the assay is thus fast (

Date: 2018
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DOI: 10.1038/s41467-018-05733-0

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