Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection

Peixin Song, Nan Zheng, Yong Liu, Chen Tian, Xilin Wu, Xiaohua Ma, Deyan Chen, Xue Zou, Guiyang Wang, Huanru Wang, Yongyang Zhang, Sufang Lu, Chao Wu and Zhiwei Wu ()
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Peixin Song: Nanjing University Medical School
Nan Zheng: Nanjing University Medical School
Yong Liu: Nanjing University Medical School
Chen Tian: Nanjing University Medical School
Xilin Wu: Nanjing University Medical School
Xiaohua Ma: Y-Clone BioMedical, Ltd., Suzhou Hi-Tech Innovation Park
Deyan Chen: Nanjing University Medical School
Xue Zou: Nanjing University Medical School
Guiyang Wang: Nanjing University Medical School
Huanru Wang: Nanjing University Medical School
Yongyang Zhang: Nanjing University Medical School
Sufang Lu: Nanjing University Medical School
Chao Wu: Nanjing University Medical School
Zhiwei Wu: Nanjing University Medical School

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-viral immune response has been reported, but humoral involvement in viral pathogenesis is poorly understood. Here we show defective serological responses to SFTSV is associated with disease fatality and a combination of B-cell and T-cell impairment contribute to disruption of anti-viral immunity. The serological profile in deceased patients is characterized by absence of specific IgG to viral nucleocapsid and glycoprotein due to failure of B-cell class switching. Expansion and impairment of antibody secretion is a signature of fatal SFTSV infection. Apoptosis of monocytes in the early stage of infection diminishes antigen-presentation by dendritic cells, impedes differentiation and function of T follicular helper cells, and contributes to failure of the virus-specific humoral response.

Date: 2018
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DOI: 10.1038/s41467-018-05746-9

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