Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area

Bryan M. Hooks (), Andrew E. Papale, Ronald F. Paletzki, Muhammad W. Feroze, Brian S. Eastwood, Jonathan J. Couey, Johan Winnubst, Jayaram Chandrashekar and Charles R. Gerfen ()
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Bryan M. Hooks: University of Pittsburgh School of Medicine
Andrew E. Papale: University of Pittsburgh School of Medicine
Ronald F. Paletzki: Laboratory of Systems Neuroscience, NIMH
Muhammad W. Feroze: University of Pittsburgh School of Medicine
Brian S. Eastwood: MBF Bioscience
Jonathan J. Couey: University of Pittsburgh School of Medicine
Johan Winnubst: Janelia Research Campus
Jayaram Chandrashekar: Janelia Research Campus
Charles R. Gerfen: Laboratory of Systems Neuroscience, NIMH

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract The striatum shows general topographic organization and regional differences in behavioral functions. How corticostriatal topography differs across cortical areas and cell types to support these distinct functions is unclear. This study contrasted corticostriatal projections from two layer 5 cell types, intratelencephalic (IT-type) and pyramidal tract (PT-type) neurons, using viral vectors expressing fluorescent reporters in Cre-driver mice. Corticostriatal projections from sensory and motor cortex are somatotopic, with a decreasing topographic specificity as injection sites move from sensory to motor and frontal areas. Topographic organization differs between IT-type and PT-type neurons, including injections in the same site, with IT-type neurons having higher topographic stereotypy than PT-type neurons. Furthermore, IT-type projections from interconnected cortical areas have stronger correlations in corticostriatal targeting than PT-type projections do. As predicted by a longstanding model, corticostriatal projections of interconnected cortical areas form parallel circuits in the basal ganglia.

Date: 2018
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DOI: 10.1038/s41467-018-05780-7

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