Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

Zhenzhen Wang, Yan Zhang, Enguo Ju, Zhen Liu, Fangfang Cao, Zhaowei Chen, Jinsong Ren () and Xiaogang Qu ()
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Zhenzhen Wang: Chinese Academy of Sciences
Yan Zhang: Chinese Academy of Sciences
Enguo Ju: Chinese Academy of Sciences
Zhen Liu: Chinese Academy of Sciences
Fangfang Cao: Chinese Academy of Sciences
Zhaowei Chen: Chinese Academy of Sciences
Jinsong Ren: Chinese Academy of Sciences
Xiaogang Qu: Chinese Academy of Sciences

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Reactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for malignant neoplasms. However, current systems are highly dependent on oxygen status and/or external stimuli to generate ROS, which greatly limit their therapeutic efficacy particularly in hypoxic tumors. Herein, we develop a biomimetic nanoflower based on self-assembly of nanozymes that can catalyze a cascade of intracellular biochemical reactions to produce ROS in both normoxic and hypoxic conditions without any external stimuli. In our formulation, PtCo nanoparticles are firstly synthesized and used to direct the growth of MnO2. By adjusting the ratio of reactants, highly-ordered MnO2@PtCo nanoflowers with excellent catalytic efficiency are obtained, where PtCo behaves as oxidase mimic and MnO2 functions as catalase mimic. In this way, the well-defined MnO2@PtCo nanoflowers not only can relieve hypoxic condition but also induce cell apoptosis significantly through ROS-mediated mechanism, thereby resulting in remarkable and specific inhibition of tumor growth.

Date: 2018
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DOI: 10.1038/s41467-018-05798-x

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