Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit

Maria Teresa Dell’Anno, Xingxing Wang, Marco Onorati, Mingfeng Li, Francesca Talpo, Yuichi Sekine, Shaojie Ma, Fuchen Liu, William B. J. Cafferty, Nenad Sestan and Stephen M. Strittmatter ()
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Maria Teresa Dell’Anno: Yale School of Medicine
Xingxing Wang: Yale School of Medicine
Marco Onorati: University of Pisa
Mingfeng Li: Yale School of Medicine
Francesca Talpo: Yale School of Medicine
Yuichi Sekine: Yale School of Medicine
Shaojie Ma: Yale School of Medicine
Fuchen Liu: Yale School of Medicine
William B. J. Cafferty: Yale School of Medicine
Nenad Sestan: Yale School of Medicine
Stephen M. Strittmatter: Yale School of Medicine

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Traumatic spinal cord injury results in persistent disability due to disconnection of surviving neural elements. Neural stem cell transplantation has been proposed as a therapeutic option, but optimal cell type and mechanistic aspects remain poorly defined. Here, we describe robust engraftment into lesioned immunodeficient mice of human neuroepithelial stem cells derived from the developing spinal cord and maintained in self-renewing adherent conditions for long periods. Extensive elongation of both graft and host axons occurs. Improved functional recovery after transplantation depends on neural relay function through the grafted neurons, requires the matching of neural identity to the anatomical site of injury, and is accompanied by expression of specific marker proteins. Thus, human neuroepithelial stem cells may provide an anatomically specific relay function for spinal cord injury recovery.

Date: 2018
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DOI: 10.1038/s41467-018-05844-8

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