Region-specific and state-dependent action of striatal GABAergic interneurons

Elodie Fino (), Marie Vandecasteele, Sylvie Perez, Frédéric Saudou and Laurent Venance
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Elodie Fino: INSERM U1050
Marie Vandecasteele: INSERM U1050
Sylvie Perez: INSERM U1050
Frédéric Saudou: INSERM U1216
Laurent Venance: INSERM U1050

Nature Communications, 2018, vol. 9, issue 1, 1-17

Abstract: Abstract Striatum processes a wide range of functions including goal-directed behavior and habit formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral striatum (DLS). GABAergic feedforward inhibition is known to control the integration of cortical information by striatal projection neurons (SPNs). Here we questioned whether this control is specific between distinct striatal functional territories. Using opto-activation and opto-inhibition of identified GABAergic interneurons, we found that different circuits are engaged in DLS and DMS, both ex vivo and in vivo: while parvalbumin interneurons efficiently control SPNs in DLS, somatostatin interneurons control SPNs in DMS. Moreover, both parvalbumin and somatostatin interneurons use a dual hyperpolarizing/depolarizing effect to control cortical input integration depending on SPN activity state: GABAergic interneurons potently inhibit spiking SPNs while in resting SPNs, they favor cortical activity summation via a depolarizing effect. Our findings establish that striatal GABAergic interneurons exert efficient territory-specific and state-dependent control of SPN activity and functional output.

Date: 2018
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DOI: 10.1038/s41467-018-05847-5

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