Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis

Chengyu Sheng, Uzma Javed, Mary Gibbs, Caixia Long, Jun Yin, Bo Qin and Quan Yuan ()
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Chengyu Sheng: National Institutes of Health
Uzma Javed: National Institutes of Health
Mary Gibbs: National Institutes of Health
Caixia Long: National Institutes of Health
Jun Yin: National Institutes of Health
Bo Qin: National Institutes of Health
Quan Yuan: National Institutes of Health

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Highly motile dendritic protrusions are hallmarks of developing neurons. These exploratory filopodia sample the environment and initiate contacts with potential synaptic partners. To understand the role for dynamic filopodia in dendrite morphogenesis and experience-dependent structural plasticity, we analyzed dendrite dynamics, synapse formation, and dendrite volume expansion in developing ventral lateral neurons (LNvs) of the Drosophila larval visual circuit. Our findings reveal the temporal coordination between heightened dendrite dynamics with synaptogenesis in LNvs and illustrate the strong influence imposed by sensory experience on the prevalence of dendritic filopodia, which regulate the formation of synapses and the expansion of dendritic arbors. Using genetic analyses, we further identified Amphiphysin (Amph), a BAR (Bin/Amphiphysin/Rvs) domain-containing protein as a required component for tuning the dynamic state of LNv dendrites and promoting dendrite maturation. Taken together, our study establishes dynamic filopodia as the key cellular target for experience-dependent regulation of dendrite development.

Date: 2018
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DOI: 10.1038/s41467-018-05871-5

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