Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

Sanja Mikulovic (), Carlos Ernesto Restrepo, Samer Siwani, Pavol Bauer, Stefano Pupe, Adriano B. L. Tort, Klas Kullander and Richardson N. Leão ()
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Sanja Mikulovic: Uppsala University
Carlos Ernesto Restrepo: Uppsala University
Samer Siwani: Uppsala University
Pavol Bauer: Uppsala University
Stefano Pupe: Uppsala University
Adriano B. L. Tort: Federal University of Rio Grande do Norte
Klas Kullander: Uppsala University
Richardson N. Leão: Uppsala University

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.

Date: 2018
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DOI: 10.1038/s41467-018-05907-w

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