A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis

Jinbo Shen (), Qiong Zhao, Xiangfeng Wang, Caiji Gao, Ying Zhu, Yonglun Zeng and Liwen Jiang ()
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Jinbo Shen: The Chinese University of Hong Kong
Qiong Zhao: The Chinese University of Hong Kong
Xiangfeng Wang: The Chinese University of Hong Kong
Caiji Gao: The Chinese University of Hong Kong
Ying Zhu: The Chinese University of Hong Kong
Yonglun Zeng: The Chinese University of Hong Kong
Liwen Jiang: The Chinese University of Hong Kong

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Plant development, defense, and many physiological processes rely on the endosomal sorting complex required for transport (ESCRT) machinery to control the homeostasis of membrane proteins by selective vacuolar degradation. Although ESCRT core components are conserved among higher eukaryotes, the regulators that control the function of the ESCRT machinery remain elusive. We recently identified a plant-specific ESCRT component, FREE1, that is essential for multivesicular body/prevacuolar compartment (MVB/PVC) biogenesis and vacuolar sorting of membrane proteins. Here we identify a plant-specific Bro1-domain protein BRAF, which regulates FREE1 recruitment to the MVB/PVC membrane by competitively binding to the ESCRT-I component Vps23. Altogether, we have successfully identified a role for BRAF, whose function as a unique evolutionary ESCRT regulator in orchestrating intraluminal vesicle formation in MVB/PVCs and the sorting of membrane proteins for degradation in plants makes it an important regulatory mechanism underlying the ESCRT machinery in higher eukaryotes.

Date: 2018
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DOI: 10.1038/s41467-018-05913-y

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