Amplification of chirality in surface-confined supramolecular bilayers

Hai Cao () and Steven De Feyter ()
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Hai Cao: KU Leuven
Steven De Feyter: KU Leuven

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract One of the most dramatic effects of supramolecular assembly is the generation of homochirality in near-racemic systems. It is normally infeasible though to flip the absolute chirality of a molecule. Here we rationalize this seemingly contradictory chiral amplification mechanism with a combined scanning tunneling microscopy (STM) and modeling study of surface-grown enantiomerically unbalanced supramolecular bilayers. We identify a chemical equilibrium between opposite but not mirror-image-related twisting molecular geometries of the pure enantiomer, and accordingly two competing aggregation pathways. The nonlinear chiral amplification effect in bilayers of near-racemic mixtures involves the biased adsorption and organization of the majority enantiomer, and the compliance of the minority enantiomer to adopt an energetically less favorable twisting molecular conformation and handed organization. By establishing a direct link between molecular building block architectures and chiral amplification effect, this study provides a general approach to gain insight into cooperative supramolecular assembly in mixed enantiomer systems.

Date: 2018
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DOI: 10.1038/s41467-018-05962-3

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