Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

Charles Van der Henst, Audrey Sophie Vanhove, Natália Carolina Drebes Dörr, Sandrine Stutzmann, Candice Stoudmann, Stéphanie Clerc, Tiziana Scrignari, Catherine Maclachlan, Graham Knott and Melanie Blokesch ()
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Charles Van der Henst: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Audrey Sophie Vanhove: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Natália Carolina Drebes Dörr: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Sandrine Stutzmann: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Candice Stoudmann: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Stéphanie Clerc: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Tiziana Scrignari: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Catherine Maclachlan: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Graham Knott: Ecole Polytechnique Fédérale de Lausanne (EPFL)
Melanie Blokesch: Ecole Polytechnique Fédérale de Lausanne (EPFL)

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Vibrio cholerae, which causes the diarrheal disease cholera, is a species of bacteria commonly found in aquatic habitats. Within such environments, the bacterium must defend itself against predatory protozoan grazers. Amoebae are prominent grazers, with Acanthamoeba castellanii being one of the best-studied aquatic amoebae. We previously showed that V. cholerae resists digestion by A. castellanii and establishes a replication niche within the host’s osmoregulatory organelle. In this study, we decipher the molecular mechanisms involved in the maintenance of V. cholerae’s intra-amoebal replication niche and its ultimate escape from the succumbed host. We demonstrate that minor virulence features important for disease in mammals, such as extracellular enzymes and flagellum-based motility, have a key role in the replication and transmission of V. cholerae in its aqueous environment. This work, therefore, describes new mechanisms that provide the pathogen with a fitness advantage in its primary habitat, which may have contributed to the emergence of these minor virulence factors in the species V. cholerae.

Date: 2018
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DOI: 10.1038/s41467-018-05976-x

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