Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue

Yuan Zhao, Mohamed Uduman, Jacqueline H. Y. Siu, Thomas J. Tull, Jeremy D. Sanderson, Yu-Chang Bryan Wu, Julian Q. Zhou, Nedyalko Petrov, Richard Ellis, Katrina Todd, Konstantia-Maria Chavele, William Guesdon, Anna Vossenkamper, Wayel Jassem, David P. D’Cruz, David J. Fear, Susan John, Dagmar Scheel-Toellner, Claire Hopkins, Estefania Moreno, Natalie L. Woodman, Francesca Ciccarelli, Susanne Heck, Steven H. Kleinstein (), Mats Bemark () and Jo Spencer ()
Additional contact information
Yuan Zhao: Guy’s Campus
Mohamed Uduman: Yale University School of Medicine
Jacqueline H. Y. Siu: University of Cambridge
Thomas J. Tull: Guy’s Campus
Jeremy D. Sanderson: Guy’s Campus
Yu-Chang Bryan Wu: King’s College London
Julian Q. Zhou: Yale University
Nedyalko Petrov: Guy’s and St. Thomas’ NHS Trust
Richard Ellis: Guy’s and St. Thomas’ NHS Trust
Katrina Todd: Guy’s and St. Thomas’ NHS Trust
Konstantia-Maria Chavele: Guy’s Campus
William Guesdon: Guy’s Campus
Anna Vossenkamper: Blizard Institute, Whitechapel
Wayel Jassem: King’s College Hospital, Denmark Hill
David P. D’Cruz: Guy’s Campus
David J. Fear: Guy’s Campus
Susan John: Guy’s Campus
Dagmar Scheel-Toellner: University of Birmingham
Claire Hopkins: Guy’s Campus
Estefania Moreno: Blizard Institute, Whitechapel
Natalie L. Woodman: Guy’s Campus
Francesca Ciccarelli: Guy’s Campus
Susanne Heck: Guy’s and St. Thomas’ NHS Trust
Steven H. Kleinstein: Yale University School of Medicine
Mats Bemark: University of Gothenburg
Jo Spencer: Guy’s Campus

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Human memory B cells and marginal zone (MZ) B cells share common features such as the expression of CD27 and somatic mutations in their IGHV and BCL6 genes, but the relationship between them is controversial. Here, we show phenotypic progression within lymphoid tissues as MZ B cells emerge from the mature naïve B cell pool via a precursor CD27−CD45RBMEM55+ population distant from memory cells. By imaging mass cytometry, we find that MZ B cells and memory B cells occupy different microanatomical niches in organised gut lymphoid tissues. Both populations disseminate widely between distant lymphoid tissues and blood, and both diversify their IGHV repertoire in gut germinal centres (GC), but nevertheless remain largely clonally separate. MZ B cells are therefore not developmentally contiguous with or analogous to classical memory B cells despite their shared ability to transit through GC, where somatic mutations are acquired.

Date: 2018
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DOI: 10.1038/s41467-018-06089-1

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