T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells

Hye-Ran Kim, YeVin Mun, Kyung-Sik Lee, Yoo-Jin Park, Jeong-Su Park, Jin-Hwa Park, Bu-Nam Jeon, Chang-Hyun Kim, Youngsoo Jun, Young-Min Hyun, Minsoo Kim, Sang-Myeong Lee, Chul-Seung Park, Sin-Hyeog Im and Chang-Duk Jun ()
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Hye-Ran Kim: Gwangju Institute of Science and Technology (GIST)
YeVin Mun: Gwangju Institute of Science and Technology (GIST)
Kyung-Sik Lee: Gwangju Institute of Science and Technology (GIST)
Yoo-Jin Park: Gwangju Institute of Science and Technology (GIST)
Jeong-Su Park: Gwangju Institute of Science and Technology (GIST)
Jin-Hwa Park: Gwangju Institute of Science and Technology (GIST)
Bu-Nam Jeon: Gwangju Institute of Science and Technology (GIST)
Chang-Hyun Kim: Gwangju Institute of Science and Technology (GIST)
Youngsoo Jun: Gwangju Institute of Science and Technology (GIST)
Young-Min Hyun: Yonsei University College of Medicine
Minsoo Kim: University of Rochester
Sang-Myeong Lee: Chonbuk National University
Chul-Seung Park: Gwangju Institute of Science and Technology (GIST)
Sin-Hyeog Im: Pohang University of Science and Technology
Chang-Duk Jun: Gwangju Institute of Science and Technology (GIST)

Nature Communications, 2018, vol. 9, issue 1, 1-19

Abstract: Abstract Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto the surface of cognate antigen-bearing APCs. Microvilli carry T cell receptors (TCR) at all stages of T cell activation and are released as large TCR-enriched, T cell microvilli particles (TMP) in a process of trogocytosis. These microvilli exclusively contain protein arrestin-domain-containing protein 1, which is directly involved in membrane budding and, in combination with vacuolar protein-sorting-associated protein 4, transforms large TMPs into smaller, exosome-sized TMPs. Notably, TMPs from CD4+ T cells are enriched with LFA-2/CD2 and various cytokines involved in activating dendritic cells. Collectively, these results demonstrate that T cell microvilli constitute “immunological synaptosomes” that carry T cell messages to APCs.

Date: 2018
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DOI: 10.1038/s41467-018-06090-8

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