Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment

Xiangdong Xue, Yee Huang, Ruonan Bo, Bei Jia, Hao Wu, Ye Yuan, Zhongling Wang, Zhao Ma, Di Jing, Xiaobao Xu, Weimin Yu, Tzu-yin Lin and Yuanpei Li ()
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Xiangdong Xue: University of California Davis
Yee Huang: University of California Davis
Ruonan Bo: University of California Davis
Bei Jia: University of California Davis
Hao Wu: University of California Davis
Ye Yuan: University of California Davis
Zhongling Wang: University of California Davis
Zhao Ma: University of California Davis
Di Jing: University of California Davis
Xiaobao Xu: University of California Davis
Weimin Yu: University of California Davis
Tzu-yin Lin: University of California Davis
Yuanpei Li: University of California Davis

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment.

Date: 2018
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DOI: 10.1038/s41467-018-06093-5

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