Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family

Valentina Klymiuk, Elitsur Yaniv, Lin Huang, Dina Raats, Andrii Fatiukha, Shisheng Chen, Lihua Feng, Zeev Frenkel, Tamar Krugman, Gabriel Lidzbarsky, Wei Chang, Marko J. Jääskeläinen, Christian Schudoma, Lars Paulin, Pia Laine, Harbans Bariana, Hanan Sela, Kamran Saleem, Chris Khadgi Sørensen, Mogens S. Hovmøller, Assaf Distelfeld, Boulos Chalhoub, Jorge Dubcovsky, Abraham B. Korol, Alan H. Schulman and Tzion Fahima ()
Additional contact information
Valentina Klymiuk: University of Haifa
Elitsur Yaniv: University of Haifa
Lin Huang: University of Haifa
Dina Raats: University of Haifa
Andrii Fatiukha: University of Haifa
Shisheng Chen: University of California
Lihua Feng: University of Haifa
Zeev Frenkel: University of Haifa
Tamar Krugman: University of Haifa
Gabriel Lidzbarsky: University of Haifa
Wei Chang: University of Helsinki
Marko J. Jääskeläinen: University of Helsinki
Christian Schudoma: Earlham Institute
Lars Paulin: University of Helsinki
Pia Laine: University of Helsinki
Harbans Bariana: The University of Sydney Plant Breeding Institute
Hanan Sela: University of Haifa
Kamran Saleem: Aarhus University
Chris Khadgi Sørensen: Aarhus University
Mogens S. Hovmøller: Aarhus University
Assaf Distelfeld: University of Haifa
Boulos Chalhoub: Institute of System and Synthetic Biology—Organization and Evolution of Complex Genomes
Jorge Dubcovsky: University of California
Abraham B. Korol: University of Haifa
Alan H. Schulman: University of Helsinki
Tzion Fahima: University of Haifa

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Yellow rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a devastating fungal disease threatening much of global wheat production. Race-specific resistance (R)-genes are used to control rust diseases, but the rapid emergence of virulent Pst races has prompted the search for a more durable resistance. Here, we report the cloning of Yr15, a broad-spectrum R-gene derived from wild emmer wheat, which encodes a putative kinase-pseudokinase protein, designated as wheat tandem kinase 1, comprising a unique R-gene structure in wheat. The existence of a similar gene architecture in 92 putative proteins across the plant kingdom, including the barley RPG1 and a candidate for Ug8, suggests that they are members of a distinct family of plant proteins, termed here tandem kinase-pseudokinases (TKPs). The presence of kinase-pseudokinase structure in both plant TKPs and the animal Janus kinases sheds light on the molecular evolution of immune responses across these two kingdoms.

Date: 2018
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DOI: 10.1038/s41467-018-06138-9

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