Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Nilah M. Ioannidis (), Wei Wang, Nicholas A. Furlotte, David A. Hinds, Carlos D. Bustamante, Eric Jorgenson, Maryam M. Asgari and Alice S. Whittemore ()
Additional contact information
Nilah M. Ioannidis: Stanford University School of Medicine
Wei Wang: Stanford University School of Medicine
Nicholas A. Furlotte: 23andMe, Inc.
David A. Hinds: 23andMe, Inc.
Carlos D. Bustamante: Stanford University School of Medicine
Eric Jorgenson: Kaiser Permanente Northern California
Maryam M. Asgari: Kaiser Permanente Northern California
Alice S. Whittemore: Stanford University School of Medicine

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer with genetic susceptibility loci identified in recent genome-wide association studies (GWAS). Transcriptome-wide association studies (TWAS) using imputed gene expression levels can identify additional gene-level associations. Here we impute gene expression levels in 6891 cSCC cases and 54,566 controls in the Kaiser Permanente Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort and 25,558 self-reported cSCC cases and 673,788 controls from 23andMe. In a discovery-validation study, we identify 19 loci containing 33 genes whose imputed expression levels are associated with cSCC at false discovery rate

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-06149-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06149-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-06149-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().