USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

Yi-Chang Wang, Yu-Syuan Wu, Chia-Yang Hung, Shao-An Wang, Ming-Jer Young, Tsung-I Hsu and Jan-Jong Hung ()
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Yi-Chang Wang: National Cheng Kung University
Yu-Syuan Wu: National Cheng Kung University
Chia-Yang Hung: National Cheng Kung University
Shao-An Wang: National Cheng Kung University
Ming-Jer Young: National Cheng Kung University
Tsung-I Hsu: Taipei Medical University
Jan-Jong Hung: National Cheng Kung University

Nature Communications, 2018, vol. 9, issue 1, 1-18

Abstract: Abstract We have previously demonstrated that USP24 is involved in cancer progression. Here, we found that USP24 expression is upregulated in M2 macrophages and lung cancer cells. Conditioned medium from USP24-knockdown M2 macrophages decreases the migratory and chemotactic activity of lung cancer cells and the angiogenic properties of human microvascular endothelial cell 1 (HMEC-1). IL-6 expression is significantly decreased in USP24-knockdown M2 macrophages and lung cancer cells, and IL-6-replenished conditioned medium restores the migratory, chemotactic and angiogenetic properties of the cells. USP24 stabilizes p300 and β-TrCP to increase the levels of histone-3 acetylation and NF-κB, and decreases the levels of DNMT1 and IκB, thereby increasing IL-6 transcription in M2 macrophages and lung cancer cells, results in cancer malignancy finally. IL-6 has previously been a target for cancer drug development. Here, we provide direct evidence to support that USP24 promotes IL-6 expression, which might be beneficial for cancer therapy.

Date: 2018
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DOI: 10.1038/s41467-018-06178-1

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