A deadly dance: the choreography of host–pathogen interactions, as revealed by single-cell technologies

Pratip K. Chattopadhyay, Mario Roederer and Diane L. Bolton ()
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Pratip K. Chattopadhyay: Precision Immunology, NYU Langone Health
Mario Roederer: ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH
Diane L. Bolton: US Military HIV Research Program, Henry M. Jackson Foundation, Walter Reed Army Institute of Research

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Pathogens have numerous mechanisms by which they replicate within a host, who in turn responds by developing innate and adaptive immune countermeasures to limit disease. The advent of high-content single-cell technologies has facilitated a greater understanding of the properties of host cells harboring infection, the host’s pathogen-specific immune responses, and the mechanisms pathogens have evolved to escape host control. Here we review these advances and argue for greater inclusion of higher resolution single-cell technologies into approaches for defining immune evasion mechanisms by pathogens.

Date: 2018
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DOI: 10.1038/s41467-018-06214-0

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