Modular DNA strand-displacement controllers for directing material expansion

Joshua Fern and Rebecca Schulman ()
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Joshua Fern: Johns Hopkins University
Rebecca Schulman: Johns Hopkins University

Nature Communications, 2018, vol. 9, issue 1, 1-8

Abstract: Abstract Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and necessitating high stimulus concentrations. Here, we show how DNA strand-displacement controllers within hydrogels can mediate size change by interpreting, amplifying, and integrating stimuli and releasing signals that direct the response. These controllers tune the time scale and degree of DNA-crosslinked hydrogel swelling and can actuate dramatic material size change in response to

Date: 2018
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DOI: 10.1038/s41467-018-06218-w

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