Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Derrick C. Wan, Stefanie L. Morgan, Andrew L. Spencley, Natasha Mariano, Erin Y. Chang, Gautam Shankar, Yunhai Luo, Ted H. Li, Dana Huh, Star K. Huynh, Jasmine M. Garcia, Cole M. Dovey, Jennifer Lumb, Ling Liu, Katharine V. Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L. Mascetti, Sharon J. Pitteri, Jordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A. Rando, Jan E. Carette, J. Fernando Bazan and Kevin C. Wang ()
Additional contact information
Derrick C. Wan: Stanford University School of Medicine
Stefanie L. Morgan: Stanford University School of Medicine
Andrew L. Spencley: Stanford University School of Medicine
Natasha Mariano: Stanford University School of Medicine
Erin Y. Chang: Stanford University School of Medicine
Gautam Shankar: Stanford University School of Medicine
Yunhai Luo: Stanford University School of Medicine
Ted H. Li: Stanford University School of Medicine
Dana Huh: Stanford University School of Medicine
Star K. Huynh: Stanford University School of Medicine
Jasmine M. Garcia: Stanford University School of Medicine
Cole M. Dovey: Stanford University School of Medicine
Jennifer Lumb: Stanford University School of Medicine
Ling Liu: Stanford University School of Medicine
Katharine V. Brown: Stanford University School of Medicine
Abel Bermudez: Stanford University School of Medicine
Richard Luong: Stanford University School of Medicine
Hong Zeng: Stanford University School of Medicine
Victoria L. Mascetti: Stanford University School of Medicine
Sharon J. Pitteri: Stanford University School of Medicine
Jordon Wang: LakePharma, Inc.
Hua Tu: LakePharma, Inc.
Marco Quarta: Stanford University School of Medicine
Vittorio Sebastiano: Stanford University School of Medicine
Roel Nusse: Stanford University School of Medicine
Thomas A. Rando: Stanford University School of Medicine
Jan E. Carette: Stanford University School of Medicine
J. Fernando Bazan: R&D Systems, Inc
Kevin C. Wang: Stanford University School of Medicine

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.

Date: 2018
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DOI: 10.1038/s41467-018-06256-4

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