Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge

Shuying Yi, Jing Zhai, Rui Niu, Guangming Zhu, Meixiang Wang, Jianguo Liu, Hua Huang, Yaping Wang, Xiuli Jing, Li Kang, Wengang Song, Yufang Shi and Hua Tang ()
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Shuying Yi: Taishan Medical University
Jing Zhai: Taishan Medical University
Rui Niu: Taishan Medical University
Guangming Zhu: Taishan Medical University
Meixiang Wang: Fudan University
Jianguo Liu: Taishan Medical University
Hua Huang: Taishan Medical University
Yaping Wang: Taishan Medical University
Xiuli Jing: Taishan Medical University
Li Kang: Taishan Medical University
Wengang Song: Taishan Medical University
Yufang Shi: Shanghai Institutes for Biological Sciences
Hua Tang: Taishan Medical University

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Eosinophil infiltration, a hallmark of allergic asthma, is essential for type 2 immune responses. How the initial eosinophil recruitment is regulated by lung dendritic cell (DC) subsets during the memory stage after allergen challenge is unclear. Here, we show that the initial eosinophil infiltration is dependent on lung cDC1s, which require nitric oxide (NO) produced by inducible NO synthase from lung CD24−CD11b+ DC2s for inducing CCL17 and CCL22 to attract eosinophils. During late phase responses after allergen challenge, lung CD24+ cDC2s inhibit eosinophil recruitment through secretion of TGF-β1, which impairs the expression of CCL17 and CCL22. Our data suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically, through secreting distinct soluble factors during the memory stage of chronic asthma after allergen challenge in the mouse.

Date: 2018
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DOI: 10.1038/s41467-018-06316-9

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