Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

Frank Lennartz, Florian Brod, Rebecca Dabbs, Kazutoyo Miura, David Mekhaiel, Arianna Marini, Matthijs M. Jore, Max M. Søgaard, Thomas Jørgensen, Willem A. Jongh, Robert W. Sauerwein, Carole A. Long, Sumi Biswas () and Matthew K. Higgins ()
Additional contact information
Frank Lennartz: University of Oxford
Florian Brod: University of Oxford
Rebecca Dabbs: University of Oxford
Kazutoyo Miura: NIH
David Mekhaiel: University of Oxford
Arianna Marini: University of Oxford
Matthijs M. Jore: Radboud University Medical Centre
Max M. Søgaard: ExpreS2ion Biotechnologies
Thomas Jørgensen: ExpreS2ion Biotechnologies
Willem A. Jongh: ExpreS2ion Biotechnologies
Robert W. Sauerwein: Radboud University Medical Centre
Carole A. Long: NIH
Sumi Biswas: University of Oxford
Matthew K. Higgins: University of Oxford

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract The quest to develop an effective malaria vaccine remains a major priority in the fight against global infectious disease. An approach with great potential is a transmission-blocking vaccine which induces antibodies that prevent establishment of a productive infection in mosquitos that feed on infected humans, thereby stopping the transmission cycle. One of the most promising targets for such a vaccine is the gamete surface protein, Pfs48/45. Here we establish a system for production of full-length Pfs48/45 and use this to raise a panel of monoclonal antibodies. We map the binding regions of these antibodies on Pfs48/45 and correlate the location of their epitopes with their transmission-blocking activity. Finally, we present the structure of the C-terminal domain of Pfs48/45 bound to the most potent transmission-blocking antibody, and provide key molecular information for future structure-guided immunogen design.

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-018-06340-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06340-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-06340-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().