Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells

Maria Montserrat Garcia Romero, Gareth McCathie, Philip Jankun and Henry Hamilton Roehl ()
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Maria Montserrat Garcia Romero: The University of Sheffield
Gareth McCathie: The University of Sheffield
Philip Jankun: The University of Sheffield
Henry Hamilton Roehl: The University of Sheffield

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Many aquatic vertebrates have a remarkable ability to regenerate limbs and tails after amputation. Previous studies indicate that reactive oxygen species (ROS) signalling initiates regeneration, but the mechanism by which this takes place is poorly understood. Developmental signalling pathways have been shown to have proregenerative roles in many systems. However, whether these are playing roles that are specific to regeneration, or are simply recapitulating their developmental functions is unclear. Here, we analyse zebrafish larval tail regeneration and find evidence that ROS released upon wounding cause repositioning of notochord cells to the damage site. These cells secrete Hedgehog ligands that are required for regeneration. Hedgehog signalling is not required for normal tail development suggesting that it has a regeneration-specific role. Our results provide a model for how ROS initiate tail regeneration, and indicate that developmental signalling pathways can play regenerative functions that are not directly related to their developmental roles.

Date: 2018
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DOI: 10.1038/s41467-018-06460-2

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