The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

V. Barra and D. Fachinetti ()
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V. Barra: CNRS, UMR 144
D. Fachinetti: CNRS, UMR 144

Nature Communications, 2018, vol. 9, issue 1, 1-17

Abstract: Abstract Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.

Date: 2018
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DOI: 10.1038/s41467-018-06545-y

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