Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery

Rui He, Yue Yin, Wenzhen Yin, Yin Li, Jing Zhao and Weizhen Zhang ()
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Rui He: and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center
Yue Yin: and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center
Wenzhen Yin: and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center
Yin Li: and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center
Jing Zhao: and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center
Weizhen Zhang: and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Roux-en-Y Gastric Bypass Surgery (RYGB) prevents the occurrence of pancreatic cell acinar carcinoma (ACC) in male and female Ngn3-Tsc1−/− mice. Ngn3 directed Cre deletion of Tsc1 gene induced the development of pancreatic ACC. The transgenic mice with sham surgery demonstrated a cancer incidence of 96.7 ± 3.35% and survival rate of 67.0 ± 1.4% at the age of 300 days. Metastasis to liver and kidney was observed in 69.7 ± 9.7% and 44.3 ± 8.01% of these animals, respectively. All animals with RYGB performed at the age of 16 weeks survived free of pancreatic ACC up to the age of 300 days. RYGB significantly attenuated the activation of mTORC1 signaling and inhibition of tumor suppressor genes: p21, p27, and p53 in pancreatic ACC. Our studies demonstrate that bariatric surgery may limit the occurrence and growth of pancreatic ACC through the suppression of mTORC1 signaling in pancreas. RYGB shows promise for intervention of both metabolic dysfunction and organ cancer.

Date: 2018
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DOI: 10.1038/s41467-018-06571-w

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