Molecular architecture and regulation of BCL10-MALT1 filaments

Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche (), Daniel Krappmann () and Katja Lammens ()
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Florian Schlauderer: Ludwig-Maximilians University
Thomas Seeholzer: Institute of Molecular Toxicology and Pharmacology, Helmholtz-Zentrum München - German Research Center for Environmental Health
Ambroise Desfosses: University Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale IBS
Torben Gehring: Institute of Molecular Toxicology and Pharmacology, Helmholtz-Zentrum München - German Research Center for Environmental Health
Mike Strauss: McGill University
Karl-Peter Hopfner: Ludwig-Maximilians University
Irina Gutsche: University Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale IBS
Daniel Krappmann: Institute of Molecular Toxicology and Pharmacology, Helmholtz-Zentrum München - German Research Center for Environmental Health
Katja Lammens: Ludwig-Maximilians University

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract The CARD11-BCL10-MALT1 (CBM) complex triggers the adaptive immune response in lymphocytes and lymphoma cells. CARD11/CARMA1 acts as a molecular seed inducing BCL10 filaments, but the integration of MALT1 and the assembly of a functional CBM complex has remained elusive. Using cryo-EM we solved the helical structure of the BCL10-MALT1 filament. The structural model of the filament core solved at 4.9 Å resolution identified the interface between the N-terminal MALT1 DD and the BCL10 caspase recruitment domain. The C-terminal MALT1 Ig and paracaspase domains protrude from this core to orchestrate binding of mediators and substrates at the filament periphery. Mutagenesis studies support the importance of the identified BCL10-MALT1 interface for CBM complex assembly, MALT1 protease activation and NF-κB signaling in Jurkat and primary CD4 T-cells. Collectively, we present a model for the assembly and architecture of the CBM signaling complex and how it functions as a signaling hub in T-lymphocytes.

Date: 2018
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DOI: 10.1038/s41467-018-06573-8

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