A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy

Guocan Yu, Shan Yu, Manik Lal Saha, Jiong Zhou, Timothy R. Cook, Bryant C. Yung, Jin Chen, Zhengwei Mao (), Fuwu Zhang, Zijian Zhou, Yijing Liu, Li Shao, Sheng Wang, Changyou Gao, Feihe Huang (), Peter J. Stang () and Xiaoyuan Chen ()
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Guocan Yu: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Shan Yu: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Manik Lal Saha: University of Utah
Jiong Zhou: Zhejiang University
Timothy R. Cook: University at Buffalo, State University of New York
Bryant C. Yung: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Jin Chen: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Zhengwei Mao: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Fuwu Zhang: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Zijian Zhou: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Yijing Liu: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Li Shao: Zhejiang University
Sheng Wang: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Changyou Gao: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Feihe Huang: Zhejiang University
Peter J. Stang: University of Utah
Xiaoyuan Chen: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health

Nature Communications, 2018, vol. 9, issue 1, 1-18

Abstract: Abstract Photodynamic therapy is an effective alternative to traditional treatments due to its minimally invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug resistance. However, it is still challenging to design photosensitizers with high singlet oxygen (1O2) quantum yields (QY) due to severe aggregation of the hydrophobic photosensitizers. Herein, we developed a discrete organoplatinum(II) metallacage using therapeutic cis-(PEt3)2Pt(OTf)2 as the building block to improve the 1O2 QY, thus achieving synergistic anticancer efficacy. The metallacage-loaded nanoparticles (MNPs) with tri-modality imaging capability allow precise diagnosis of tumor and real-time monitoring the delivery, biodistribution, and excretion of the MNPs. MNPs exhibited excellent anti-metastatic effect and superior anti-tumor performance against U87MG, drug resistant A2780CIS, and orthotopic tumor models, ablating the tumors without recurrence after a single treatment. Gene chip analyses confirmed the contribution of different therapeutic modalities to the tumor abrogation. This supramolecular platform holds potential in precise cancer theranostics.

Date: 2018
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DOI: 10.1038/s41467-018-06574-7

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