S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity

Beimi Cui, Qiaona Pan, David Clarke, Marisol Ochoa Villarreal, Saima Umbreen, Bo Yuan, Weixing Shan, Jihong Jiang and Gary J. Loake ()
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Beimi Cui: Jiangsu Normal University
Qiaona Pan: Jiangsu Normal University
David Clarke: University of Edinburgh
Marisol Ochoa Villarreal: University of Edinburgh
Saima Umbreen: University of Edinburgh
Bo Yuan: Jiangsu Normal University
Weixing Shan: Northwest A&F University
Jihong Jiang: Jiangsu Normal University
Gary J. Loake: Jiangsu Normal University

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Nitric oxide (NO) orchestrates a plethora of incongruent plant immune responses, including the reprograming of global gene expression. However, the cognate molecular mechanisms remain largely unknown. Here we show a zinc finger transcription factor (ZF-TF), SRG1, is a central target of NO bioactivity during plant immunity, where it functions as a positive regulator. NO accumulation promotes SRG1 expression and subsequently SRG1 occupies a repeated canonical sequence within target promoters. An EAR domain enables SRG1 to recruit the corepressor TOPLESS, suppressing target gene expression. Sustained NO synthesis drives SRG1 S-nitrosylation predominantly at Cys87, relieving both SRG1 DNA binding and transcriptional repression activity. Accordingly, mutation of Cys87 compromises NO-mediated control of SRG1-dependent transcriptional suppression. Thus, the SRG1-SNO formation may contribute to a negative feedback loop that attenuates the plant immune response. SRG1 Cys87 is evolutionary conserved and thus may be a target for redox regulation of ZF-TF function across phylogenetic kingdoms.

Date: 2018
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DOI: 10.1038/s41467-018-06578-3

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