Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

Huiyi Liang, Bo Peng, Cong Dong, Lixin Liu (), Jiaji Mao, Song Wei, Xinlu Wang, Hanshi Xu, Jun Shen (), Hai-Quan Mao, Xiaohu Gao, Kam W. Leong () and Yongming Chen ()
Additional contact information
Huiyi Liang: Sun Yat-sen University
Bo Peng: Sun Yat-sen University
Cong Dong: Sun Yat-sen University
Lixin Liu: Sun Yat-sen University
Jiaji Mao: Sun Yat-sen University
Song Wei: General Hospital of Guangzhou Military Command of PLA
Xinlu Wang: General Hospital of Guangzhou Military Command of PLA
Hanshi Xu: The First Affiliated Hospital, Sun Yat-sen University
Jun Shen: Sun Yat-sen University
Hai-Quan Mao: Sun Yat-sen University
Xiaohu Gao: Sun Yat-sen University
Kam W. Leong: Sun Yat-sen University
Yongming Chen: Sun Yat-sen University

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that ~40 nm cationic nanoparticles (cNP) can scavenge cfDNA derived from RA patients and inhibit the activation of primary synovial fluid monocytes and fibroblast-like synoviocytes. Using clinical scoring, micro-CT images, MRI, and histology, we show that intravenous injection of cNP into a CpG-induced mouse model or collagen-induced arthritis rat model can relieve RA symptoms including ankle and tissue swelling, and bone and cartilage damage. This culminates in the manifestation of partial mobility recovery of the treated rats in a rotational cage test. Mechanistic studies on intracellular trafficking and biodistribution of cNP, as well as measurement of cytokine expression in the joints and cfDNA levels in systemic circulation and inflamed joints also correlate with therapeutic outcomes. This work suggests a new direction of nanomedicine in treating inflammatory diseases.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-06603-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06603-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-06603-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().