SOX17 regulates uterine epithelial–stromal cross-talk acting via a distal enhancer upstream of Ihh

Xiaoqiu Wang, Xilong Li, Tianyuan Wang, San-Pin Wu, Jae-Wook Jeong, Tae Hoon Kim, Steven L. Young, Bruce A. Lessey, Rainer B. Lanz, John P. Lydon and Francesco J. DeMayo ()
Additional contact information
Xiaoqiu Wang: National Institute of Environmental Health Sciences
Xilong Li: Baylor College of Medicine
Tianyuan Wang: National Institute of Environmental Health Sciences
San-Pin Wu: National Institute of Environmental Health Sciences
Jae-Wook Jeong: Michigan State University
Tae Hoon Kim: Michigan State University
Steven L. Young: University of North Carolina
Bruce A. Lessey: University of South Carolina School of Medicine
Rainer B. Lanz: Baylor College of Medicine
John P. Lydon: Baylor College of Medicine
Francesco J. DeMayo: National Institute of Environmental Health Sciences

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Mammalian pregnancy depends on the ability of the uterus to support embryo implantation. Previous studies reveal the Sox17 gene as a downstream target of the Pgr-Gata2-dependent transcription network that directs genomic actions in the uterine endometrium receptive for embryo implantation. Here, we report that ablating Sox17 in the uterine epithelium impairs leukemia inhibitory factor (LIF) and Indian hedgehog homolog (IHH) signaling, leading to failure of embryo implantation. In vivo deletion of the SOX17-binding region 19 kb upstream of the Ihh locus by CRISPR-Cas technology reduces Ihh expression specifically in the uterus and alters proper endometrial epithelial–stromal interactions, thereby impairing pregnancy. This SOX17-binding interval is also bound by GATA2, FOXA2, and PGR. This cluster of transcription factor binding is common in 737 uterine genes and may represent a key regulatory element essential for uterine epithelial gene expression.

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/s41467-018-06652-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06652-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-06652-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().