Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88

Bjørn E. V. Koch, Shuxin Yang, Gerda Lamers, Jens Stougaard and Herman P. Spaink ()
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Bjørn E. V. Koch: Leiden University
Shuxin Yang: Leiden University
Gerda Lamers: Leiden University
Jens Stougaard: Aarhus University
Herman P. Spaink: Leiden University

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Host pathways mediating changes in immune states elicited by intestinal microbial colonization are incompletely characterized. Here we describe alterations of the host immune state induced by colonization of germ-free zebrafish larvae with an intestinal microbial community or single bacterial species. We show that microbiota-induced changes in intestinal leukocyte subsets and whole-body host gene expression are dependent on the innate immune adaptor gene myd88. Similar patterns of gene expression are elicited by colonization with conventional microbiome, as well as mono-colonization with two different zebrafish commensal bacterial strains. By studying loss-of-function myd88 mutants, we find that colonization suppresses Myd88 at the mRNA level. Tlr2 is essential for microbiota-induced effects on myd88 transcription and intestinal immune cell composition.

Date: 2018
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DOI: 10.1038/s41467-018-06658-4

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