Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells

Marco Matos, Anthony Bosson, Ilse Riebe, Clare Reynell, Joanne Vallée, Isabel Laplante, Aude Panatier, Richard Robitaille () and Jean-Claude Lacaille ()
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Marco Matos: Université de Montréal
Anthony Bosson: Université de Montréal
Ilse Riebe: Université de Montréal
Clare Reynell: Université de Montréal
Joanne Vallée: Université de Montréal
Isabel Laplante: Université de Montréal
Aude Panatier: Neurocentre Magendie
Richard Robitaille: Université de Montréal
Jean-Claude Lacaille: Université de Montréal

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Astrocytes are important regulators of excitatory synaptic networks. However, astrocytes regulation of inhibitory synaptic systems remains ill defined. This is particularly relevant since GABAergic interneurons regulate the activity of excitatory cells and shape network function. To address this issue, we combined optogenetics and pharmacological approaches, two-photon confocal imaging and whole-cell recordings to specifically activate hippocampal somatostatin or paravalbumin-expressing interneurons (SOM-INs or PV-INs), while monitoring inhibitory synaptic currents in pyramidal cells and Ca2+ responses in astrocytes. We found that astrocytes detect SOM-IN synaptic activity via GABABR and GAT-3-dependent Ca2+ signaling mechanisms, the latter triggering the release of ATP. In turn, ATP is converted into adenosine, activating A1Rs and upregulating SOM-IN synaptic inhibition of pyramidal cells, but not PV-IN inhibition. Our findings uncover functional interactions between a specific subpopulation of interneurons, astrocytes and pyramidal cells, involved in positive feedback autoregulation of dendritic inhibition of pyramidal cells.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06731-y

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DOI: 10.1038/s41467-018-06731-y

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