Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens

David Ottenheimer (), Jocelyn M. Richard and Patricia H. Janak ()
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David Ottenheimer: Johns Hopkins University
Jocelyn M. Richard: Johns Hopkins University
Patricia H. Janak: Johns Hopkins University

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract The ventral striatopallidal system, a basal ganglia network thought to convert limbic information into behavioral action, includes the nucleus accumbens (NAc) and the ventral pallidum (VP), typically described as a major output of NAc. Here, to investigate how reward-related information is transformed across this circuit, we measure the activity of neurons in NAc and VP when rats receive two highly palatable but differentially preferred rewards, allowing us to track the reward-specific information contained within the neural activity of each region. In VP, we find a prominent preference-related signal that flexibly reports the relative value of reward outcomes across multiple conditions. This reward-specific firing in VP is present in a greater proportion of the population and arises sooner following reward delivery than in NAc. Our findings establish VP as a preeminent value signaler and challenge the existing model of information flow in the ventral basal ganglia.

Date: 2018
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DOI: 10.1038/s41467-018-06849-z

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