Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Marco Matejcic, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Kan Wang, Xin Sheng, Ali Amin Al Olama, Fredrick R. Schumacher, Sue A. Ingles, Koveela Govindasami, Sara Benlloch, Sonja I. Berndt, Demetrius Albanes, Stella Koutros, Kenneth Muir, Victoria L. Stevens, Susan M. Gapstur, Catherine M. Tangen, Jyotsna Batra, Judith Clements, Henrik Gronberg, Nora Pashayan, Johanna Schleutker, Alicja Wolk, Catharine West, Lorelei Mucci, Peter Kraft, Géraldine Cancel-Tassin, Karina D. Sorensen, Lovise Maehle, Eli M. Grindedal, Sara S. Strom, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ruth C. Travis, Robert J. Hamilton, Barry Rosenstein, Yong-Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, Jeanette T. Bensen, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanford, Cezary Cybulski, Børge G. Nordestgaard, Hermann Brenner, Christiane Maier, Jeri Kim, Manuel R. Teixeira, Susan L. Neuhausen, Kim Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Manuela Gago-Dominguez, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa A. Cannon-Albright, Hardev Pandha, Stephen N. Thibodeau, Daniel J. Schaid, Fredrik Wiklund, Stephen J. Chanock, Douglas F. Easton, Rosalind A. Eeles, Zsofia Kote-Jarai, David V. Conti and Christopher A. Haiman ()
Additional contact information
Marco Matejcic: University of Southern California/Norris Comprehensive Cancer Center
Edward J. Saunders: The Institute of Cancer Research
Tokhir Dadaev: The Institute of Cancer Research
Mark N. Brook: The Institute of Cancer Research
Kan Wang: University of Southern California/Norris Comprehensive Cancer Center
Xin Sheng: University of Southern California/Norris Comprehensive Cancer Center
Ali Amin Al Olama: University of Cambridge
Fredrick R. Schumacher: Case Western Reserve University
Sue A. Ingles: University of Southern California/Norris Comprehensive Cancer Center
Koveela Govindasami: The Institute of Cancer Research
Sara Benlloch: The Institute of Cancer Research
Sonja I. Berndt: National Cancer Institute, NIH
Demetrius Albanes: National Cancer Institute, NIH
Stella Koutros: National Cancer Institute, NIH
Kenneth Muir: University of Manchester
Victoria L. Stevens: Epidemiology Research Program, American Cancer Society
Susan M. Gapstur: Epidemiology Research Program, American Cancer Society
Catherine M. Tangen: SWOG Statistical Center, Fred Hutchinson Cancer Research Center
Jyotsna Batra: Queensland University of Technology
Judith Clements: Queensland University of Technology
Henrik Gronberg: Karolinska Institute
Nora Pashayan: University of Cambridge
Johanna Schleutker: University of Turku
Alicja Wolk: Karolinska Institutet
Catharine West: University of Manchester
Lorelei Mucci: Harvard School of Public Health
Peter Kraft: Harvard T.H. Chan School of Public Health
Géraldine Cancel-Tassin: GRC N°5 ONCOTYPE-URO, UPMC Univ Paris 06, Tenon Hospital
Karina D. Sorensen: Aarhus University Hospital
Lovise Maehle: Oslo University Hospital
Eli M. Grindedal: Oslo University Hospital
Sara S. Strom: The University of Texas MD Anderson Cancer Center
David E. Neal: University of Cambridge
Freddie C. Hamdy: University of Oxford
Jenny L. Donovan: University of Bristol, Canynge Hall
Ruth C. Travis: University of Oxford
Robert J. Hamilton: Princess Margaret Cancer Centre
Barry Rosenstein: Icahn School of Medicine at Mount Sinai
Yong-Jie Lu: Queen Mary University of London
Graham G. Giles: Cancer Council Victoria
Adam S. Kibel: Brigham and Womens Hospital
Ana Vega: Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS
Jeanette T. Bensen: University of North Carolina
Manolis Kogevinas: Barcelona Institute for Global Health (ISGlobal)
Kathryn L. Penney: Brigham and Women’s Hospital/Harvard Medical School
Jong Y. Park: Moffitt Cancer Center
Janet L. Stanford: Fred Hutchinson Cancer Research Center
Cezary Cybulski: Pomeranian Medical University
Børge G. Nordestgaard: University of Copenhagen
Hermann Brenner: German Cancer Research Center (DKFZ)
Christiane Maier: University Hospital Ulm
Jeri Kim: The University of Texas MD Anderson Cancer Center
Manuel R. Teixeira: Portuguese Oncology Institute of Porto
Susan L. Neuhausen: Beckman Research Institute of the City of Hope
Kim Ruyck: Basic Medical Sciences
Azad Razack: University of Malaya
Lisa F. Newcomb: Fred Hutchinson Cancer Research Center
Davor Lessel: University Medical Center Hamburg-Eppendorf
Radka Kaneva: Medical University of Sofia
Nawaid Usmani: University of Alberta
Frank Claessens: KU Leuven
Paul A. Townsend: University of Manchester
Manuela Gago-Dominguez: Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS
Monique J. Roobol: Erasmus University Medical Center
Florence Menegaux: University Paris-Sud, University Paris-Saclay
Kay-Tee Khaw: University of Cambridge
Lisa A. Cannon-Albright: University of Utah School of Medicine
Hardev Pandha: The University of Surrey, Guildford
Stephen N. Thibodeau: Mayo Clinic
Daniel J. Schaid: Mayo Clinic
Fredrik Wiklund: Karolinska Institute
Stephen J. Chanock: National Cancer Institute, NIH
Douglas F. Easton: University of Cambridge
Rosalind A. Eeles: The Institute of Cancer Research
Zsofia Kote-Jarai: The Institute of Cancer Research
David V. Conti: University of Southern California/Norris Comprehensive Cancer Center
Christopher A. Haiman: University of Southern California/Norris Comprehensive Cancer Center

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p

Date: 2018
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DOI: 10.1038/s41467-018-06863-1

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