Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces

Xiaoming Cai, Jun Dong, Jing Liu, Huizhen Zheng, Chitrada Kaweeteerawat, Fangjun Wang, Zhaoxia Ji () and Ruibin Li ()
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Xiaoming Cai: Soochow University
Jun Dong: Wuhan Academy of Agricultural Science
Jing Liu: Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS)
Huizhen Zheng: Soochow University
Chitrada Kaweeteerawat: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA)
Fangjun Wang: Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS)
Zhaoxia Ji: University of California
Ruibin Li: Soochow University

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure–activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for a representative ENM, Fe2O3, by metabolomics and proteomics analyses. The established nano-SAR profile allows the visualizing of the contributions of seven basic properties of Fe2O3 to its diverse bio-effects. For instance, although surface reactivity is responsible for Fe2O3-induced cell migration, the inflammatory effects of Fe2O3 are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs are examined in THP-1 cells and animal lungs, which allow us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1-dependent signaling. This study provides more insights for nano-SARs, and may facilitate the tailored design of ENMs to render them desired bio-effects.

Date: 2018
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DOI: 10.1038/s41467-018-06869-9

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