Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA

Julius Gudmundsson (), Jon K. Sigurdsson, Lilja Stefansdottir, Bjarni A. Agnarsson, Helgi J. Isaksson, Olafur A. Stefansson, Sigurjon A. Gudjonsson, Daniel F. Gudbjartsson, Gisli Masson, Michael L. Frigge, Simon N. Stacey, Patrick Sulem, Gisli H. Halldorsson, Vinicius Tragante, Hilma Holm, Gudmundur I. Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Thorvaldur Jonsson, Eirikur Jonsson, Rosa B. Barkardottir, Rafn Hilmarsson, Folkert W. Asselbergs, Gudmundur Geirsson, Unnur Thorsteinsdottir, Thorunn Rafnar, Gudmar Thorleifsson and Kari Stefansson ()
Additional contact information
Julius Gudmundsson: deCODE genetics/AMGEN
Jon K. Sigurdsson: deCODE genetics/AMGEN
Lilja Stefansdottir: deCODE genetics/AMGEN
Bjarni A. Agnarsson: Landspitali-University Hospital
Helgi J. Isaksson: Landspitali-University Hospital
Olafur A. Stefansson: deCODE genetics/AMGEN
Sigurjon A. Gudjonsson: deCODE genetics/AMGEN
Daniel F. Gudbjartsson: deCODE genetics/AMGEN
Gisli Masson: deCODE genetics/AMGEN
Michael L. Frigge: deCODE genetics/AMGEN
Simon N. Stacey: deCODE genetics/AMGEN
Patrick Sulem: deCODE genetics/AMGEN
Gisli H. Halldorsson: deCODE genetics/AMGEN
Vinicius Tragante: deCODE genetics/AMGEN
Hilma Holm: deCODE genetics/AMGEN
Gudmundur I. Eyjolfsson: The Clinical Laboratory in Mjodd
Olof Sigurdardottir: Akureyri Hospital
Isleifur Olafsson: Landspitali-University Hospital
Thorvaldur Jonsson: Landspitali-University Hospital
Eirikur Jonsson: Landspitali-University Hospital
Rosa B. Barkardottir: Landspitali University Hospital
Rafn Hilmarsson: Landspitali-University Hospital
Folkert W. Asselbergs: University of Utrecht
Gudmundur Geirsson: Landspitali-University Hospital
Unnur Thorsteinsdottir: deCODE genetics/AMGEN
Thorunn Rafnar: deCODE genetics/AMGEN
Gudmar Thorleifsson: deCODE genetics/AMGEN
Kari Stefansson: deCODE genetics/AMGEN

Nature Communications, 2018, vol. 9, issue 1, 1-8

Abstract: Abstract Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P

Date: 2018
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DOI: 10.1038/s41467-018-06920-9

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